The Replenix skincare line is the brainchild of Topix Pharmaceuticals, a New York-based company founded in 1981 by Stanley Shaffer. The primary effective ingredient in all of the Replenix formulas is polyphenol, which is extracted from green tea. The benefits of polyphenols have been well documented, both for their health and cosmetic advantages. Green tea has been proven to reduce damage from sun exposure by combating environmental free radicals that are found in harmful UV rays.